Postdoctoral Researcher

Job title:

Postdoctoral Researcher

Company

University Health Network

Job description

Company DescriptionThe University Health Network, where “above all else the needs of patients come first”, encompasses Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute and the Michener Institute of Education. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of ground breaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.Job DescriptionThe Princess Margaret Cancer Centre, a world-leading cancer research institution, invites applications for a Postdoctoral Fellow position. The laboratories Thomas Kislinger and Mohammad Mazhab-Jafari are seeking a highly motivated and skilled scientist with expertise in mass spectrometry to join our cutting-edge research program. This position offers the opportunity to work at the forefront of cancer research, exploring the intricate mechanisms of protein interactions and post-translational modifications in cancer biology.Union: Non-UnionSite: Princess Margaret Cancer CentreDepartment: ResearchReports to: Dr. Mohammad Mazhab-Jafari and Dr. Thomas KislingerWork Model: On site
Hours: 37.5
Salary: To commensurate with experience and consistent with UHN compensation policy
Shifts: Day
Status: Contract
Closing Date: March 31, 2025Position summary:The successful candidate will lead a project focused on studying fatty acid synthase (FASN) protein interactions and post-translational modifications (PTMs) across diverse cancer cell lines. Utilizing advanced affinity-purification mass spectrometry (AP-MS) techniques and cryo-electron microscopy (cryoEM), the project aims to provide deep insights into the role of FASN in cancer. The candidate will have access to state-of-the-art mass spectrometry and cryoEM instrumentation and will receive comprehensive training in these cutting-edge technologies.QualificationsDuties:

• The postdoctoral fellow will be responsible for growing and maintaining cancer cell lines, conducting affinity-purification experiments, and performing mass spectrometry analyses to characterize protein interactions and modifications.
• The role also includes analyzing complex datasets to identify key biological insights (e.g., identify PTMs from AP-MS data)
• Collaborating with multidisciplinary teams to integrate findings
• Preparing high-quality manuscripts for publication in leading scientific journals.
• Additional responsibilities include presenting research findings at conferences
• Participating in the mentoring of junior lab members.

Qualifications:

• PhD in Biochemistry, Molecular Biology, or a related field (awarded within the past three years).
• Expertise in mass spectrometry techniques, particularly AP-MS.
• Experience in cell culturing techniques is preferred.
• Proficiency in data analysis and bioinformatics tools.
• Strong communication and organizational skills, with the ability to work both independently and collaboratively.
• Familiarity with cryoEM is an asset but not required; training will be provided.

Additional InformationWhy join UHN?
In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP

) * Close access to Transit and UHN shuttle service

• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN’s attendance management program, to be eligible for consideration.All applications must be submitted before the posting close date.UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.We thank all applicants for their interest, however, only those selected for further consideration will be contacted.

Expected salary

Location

Toronto, ON

Job date

Wed, 15 Jan 2025 23:54:17 GMT

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